Furthermore, the selectivity of these synthesized compounds was observed for being drastically increased for HDAC6 in comparison with HDAC1 and HDAC8. Compound 96c turned out being the most effective with the best HDAC6 activity but reasonable FGER1 activity.
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The scope of boronic acid substitution was investigated inside the response of a range of formylboronic acids 1b–file with DIAD (2b) accompanied by cyclization (Scheme two).
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